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A pathogenic variant does result in medical problems or sickness as the transform does influence how the gene works. A pathogenic variant might also be called a mutation or even a disease-causing variant. 

Each youngster of someone using an autosomal dominant disorder provides a fifty% (1 in two) probability of inheriting the variant as well as the ailment. Normally, small children who inherit a dominant variant will have the ailment, but They could be kind of seriously impacted than their mother or father.

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DNA is present in the nucleus of the cell and, in human beings, is packaged into 23 pairs of chromosomes with the assistance of Specific proteins. 

These genetic variations are usually not inherited from a dad or mum, but transpire possibly randomly or due to some environmental exposure (such as cigarette smoke).

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